he Food and Drug Administration (FDA) has approved updated labeling for Biktarvy (bictegravir, emtricitabine, and tenofovir alafenamide; Gilead) to include treatment of both adult and pediatric patients weighing at least 25kg with HIV-1 who have no antiretroviral treatment history or to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA <50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to the individual components of Biktarvy. Previously, the combination therapy had only been approved for adults.
- Published
- 20 June 2019
- From
-
Monthly Prescribing Reference
CytoDyn, a late-stage biotechnology company developing leronlimab (PRO 140), a CCR5 antagonist with the potential for multiple therapeutic indications, announced today significant progress in securing the therapeutic effect and safety of leronlimab (PRO 140) with the development of an assay that can reliably determine a patient’s CCR5 status.
- Published
- 20 June 2019
- From
-
CytoDyn press release
The researchers concluded that “a reduced dose of efavirenz (a 400 mg dose is now recommended as an alternative first-line regimen also by [World Health Organization] can lead to a significant decline in total cholesterol and LDL and should be used especially in patients with cardiovascular or metabolic comorbidities.”
- Published
- 19 June 2019
- From
-
Infectious Disease Advisor
Public mistrust of vaccines means the world is taking a step backwards in the fight against deadly yet preventable infectious diseases, warn experts. A Wellcome Trust analysis includes responses from more than 140,000 people in over 140 countries. Eastern Europe was the world region most sceptical of vaccines, with only 50% of people confident vaccines were safe, with Western Europe in second place, at 59%. People in France were also among the most likely to disagree that vaccines were effective, at 19%, and to disagree that vaccines were important for children to have, at 10%. The World Health Organization lists vaccine hesitancy as one of the top 10 threats to global health.
- Published
- 19 June 2019
- From
-
BBC
Drug-drug interactions are
common in people over the age of 65 living with HIV and this substantially increases
healthcare costs in France. Published in Open
Forum Infectious Diseases,
- Published
- 19 June 2019
- By
- Alain Volny-Anne
Treatment for HIV-positive individuals with persistent viral
replication despite therapy with multiple regimens is effective and safe over
two years when it omits nucleoside reverse transcriptase inhibitors
- Published
- 13 June 2019
- By
- Michael Carter
CytoDyn is moving their PRO 140 product candidate closer towards an FDA approval in HIV.
- Published
- 12 June 2019
- From
-
Seeking Alpha
The HIV cure effort suffered a potential setback this week, as researchers reported an association between having two copies of the CCR5-∆32 mutation and shorter survival.
- Published
- 11 June 2019
- From
-
NEJM Journal Watch
Researchers in Sydney, Australia have identified a patient who appears to have spontaneously cleared his own HIV infection without any medication, many years after he
- Published
- 11 June 2019
- By
- Gus Cairns
The Trump administration on Wednesday announced major new restrictions in funding of research involving human fetal tissue — a product that many scientists say is irreplaceable in studying certain diseases — in a move that immediately ended a decades-long partnership with UCSF involving HIV research.
- Published
- 07 June 2019
- From
-
San Francisco Chronicle
Antiretroviral drug chartA one-page reference guide to the anti-HIV drugs licensed for use in the UK or European Union, with information on formulation, dosing, key side effects and food requirements.
Your next stepsA booklet with information for people who’ve just found
out they have HIV.
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